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The COSMOSIL¢ç5C18-MS-II column, taking advantage of a new end capping treatment can replace the COSMOSIL¢ç
5C18-MS. The silica gel is end capped with polar groups for shielding effect, based on the chemical property of the
packed silica gel to draw highly polar components from the mobile phase. As a result, the new end capping provides
improved peak shape for basic compounds. The absorption of the silica gel is controlled because it does not interact with
N atoms, therefore suitable for the separation of chelating compounds. Another advantage is that the 5C18-MS-II has
similar retention characteristics to the 5C18-MS series: the HPLC conditions for the 5C18-MS are applicable to the newly
developed column, 5C18-MS-II.
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